Treatment of hayfever with loratadine a new non sedating antihistamine
It is important to note that impaired motor activity and fatigue can also be associated with antihistamine use, and this should be considered when selecting the appropriate AR medication.In patients previously sensitized to specific aeroallergens, subsequent exposure induces an immunoglobulin E–mediated biochemical cascade resulting in mast cell/basophil degranulation and release of inflammatory mediators.Similar results were observed in another study of fexofenadine and cetirizine with 821 patients.Also, the combined incidence of fatigue or drowsiness was greater in the cetirizine group (9%) than in the fexofenadine or placebo groups (4% each); the difference was significant for cetirizine versus fexofenadine ( = .018).Because Allegra provides powerful efficacy in AR without the risk of sedation, it is a good first choice when making recommendations in this class.Researchers from the University of Chicago have demonstrated that corticosteroid nasal sprays are more effective than antihistamines when used "as needed" for treatment of seasonal allergies.
Quality-of-life issues associated with AR include sleep disturbance, irritability, depression, productivity loss, slowed psychomotor response times, impaired learning and decision making, and fatigue.Most take them sporadically, in response to symptoms."Changing the current guidelines to match patient practice would help more people and reduce health care costs," said Robert Naclerio, M.They are appropriate for use in the pediatric population, and 3 products, Allegra, Claritin, and Zyrtec, are FDA-approved as liquid formulations for use in children 2 years and older.
Dosage information for OTC second-generation antihistamines is listed in the Table.Loratadine and cetirizine are also contraindicated in patients with hepatic disease; however, fexofenadine is not.