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15-Feb-2020 11:13

The reference category was defined as a discrepancy within 2 days of the median. Delivery outcomes were included if adverse outcomes were expected to be more frequent among large infants at birth because a larger fetal size may be apparent at the time of the dating scan: prolonged second stage of labor (6622, O63.1), delivery by forceps or vacuum extractor (6695, O81), delivery by cesarean section (6697, O82), shoulder dystocia (6604, O66.0), postpartum hemorrhage (666, O72), and perineal laceration: third or fourth degree (6642, 6643, O70.2, O70.3) (Supplementary Table 1).The remaining pregnancies were defined as a small negative or small positive discrepancy (Fig. To check for any association with the discrepancy between dating methods to infant size at birth, we included small for gestational age (SGA) and large for gestational age (LGA).To assess associations between discrepancy of pregnancy dating methods and adverse pregnancy, delivery, and neonatal outcomes, odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for discrepancy categories among all singleton births from the Medical Birth Register (1995–2010) with estimated date of delivery (EDD) by last menstrual period (LMP) minus EDD by ultrasound (US) −20 to 20 days. Odds for diabetes and preeclampsia were higher in pregnancies with negative discrepancy, and for most delivery outcomes in case of large positive discrepancy ( 9 to 20 days): shoulder dystocia [OR 1.16 (95% CI 1.01–1.33)] and sphincter injuries [OR 1.13 (95% CI 1.09–1.17)].

In model 2, fetal sex was added to the first model with female as the reference category.

NNT should in this context be interpreted as number needed to follow up more closely to possibly detect the specific adverse outcome.